Doncaster summer signing James O'Connor (stomach) could make his competitive debut while fellow defender Sean McDaid is also fit.
But goalkeeper Andy Warrington has been ruled out for up to four months due to ankle ligament damage.
Crewe manager Dario Gradi will be able to select from an unchanged squad.
Centre-back Neil Cox is facing another couple of weeks on the sidelines with a hamstring injury, while midfielder Lee Bell (foot) is also out of action.
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