Wycombe missed the chance to close in on the League Two play-offs with a frustrating goalless draw.
A late scramble saw Grimsby sub Ronnie Bull to throw himself in front of Nathan Tyson's goalbound drive to earn Russell Slade's mid-table team a point.
Wycombe's best chance came when forward Steve Claridge turned and shot in the box to force a save from impressive Grimsby keeper Anthony Williams.
The visitors' 22-goal top-scorer Tyson failed to shine for John Gorman's side.