Palermo 1 - 0 Slavia Prague
Renzo Barbera (8,063)
Palermo win on Away Goals Rule Agg: 2 - 2

Rapid Bucuresti 2 - 0 Hertha Berlin
FinalGiulesti Stadium (15,000)
Rapid advance on Agg: 3 - 0

Levski Sofia 2 - 0 Artmedia Petrzalka
Georgi Asparuchov Stadium (23,441)
Levski Sofia advance Agg: 3 - 0

Shakhtar Donetsk 0 - 0 Lille
RSK Olympyiskyi (23,250)
Lille advance Agg: 2 - 3

Steaua Bucuresti 0 - 1 Heerenveen
Stadionul Ghencea (50,000)
Steaua Bucuresti advance Agg: 3 - 2

Zenit St Petersburg 2 - 1 Rosenborg
Petrovski Stadium (21,500)
Zenit St Petersburg advance Agg: 4 - 1

Hamburg SV 2 - 0 FC Thun
AOL-Arena (40,254)
Hamburg SV advance Agg: 2 - 1

Strasbourg 0 - 0 Liteks Lovetch
La Meinau (9,610)
Strasbourg advance Agg: 2 - 0

AZ Alkmaar 2 - 1 Real Betis
Alkmaarder Hout (11,000)
AZ Alkmaar advance After Extra Time Agg: 2 - 3


Lens 1 - 0 Udinese
Felix-Bollaert (26,292)
Lens advance Agg: 1 - 3


Marseille 2 - 1 Bolton
Velodrome (38,351)
Marseille advance Agg: 2 - 1


Middlesbrough 0 - 1 VfB Stuttgart
The Riverside Stadium (24,018)
Middlesbrough advance on Away Goals Rule Agg: 2 - 2


Monaco 1 - 1 Basle
Stade Louis II (11,955)
Basle advance Agg: 1 - 2


Roma 2 - 1 Club Brugge
Olimpico (15,209) Roma 2 - 1 Club Brugge
Roma advance Agg: 4 - 2


FC Sevilla 2 - 0 Lokomotiv Moscow
Estadio Ramon Sanchez Pizjuan
Sevilla advance Agg: 3 - 0


Espanyol 0 - 3 Schalke 04
Montjuic Stadium (18,100)
Schalke 04 advance Agg: 1 - 5